Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reticuloendothelial and mesangial function in murine immune complex glomerulonephritis.

P E Hoffsten, A Swerdlin, M Bartell

    Kidney International
    |February 1, 1979
    PubMed
    Summary

    This study found that mice with nephritis from lymphocytic choriomeningitis (LCM) virus infection show increased glomerular accumulation of immune complexes. Their reticuloendothelial system function is impaired, leading to slower clearance of these materials.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Creation of a Pediatric Sedation Risk Assessment Scoring System: A Novel Method to Stratify Risk.

    Journal of pediatric intensive care·2024
    Same author

    Patient perspective on remission in rheumatoid arthritis: Validation of patient reported outcome instruments to measure absence of disease activity.

    Seminars in arthritis and rheumatism·2021
    Same author

    The prevalence of gout and hyperuricaemia in Australia: An updated systematic review.

    Seminars in arthritis and rheumatism·2020
    Same author

    Colchicine is not effective for reducing osteoarthritic hand pain compared to placebo: a randomised, placebo-controlled trial (COLAH).

    Osteoarthritis and cartilage·2020
    Same author

    Prevalence and associations of gout and hyperuricaemia: results from an Australian population-based study.

    Internal medicine journal·2016
    Same author

    Supplementation with omega-3 fish oil has no effect on bone mineral density in adults with knee osteoarthritis: a 2-year randomized controlled trial.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2015

    Area of Science:

    • Immunology
    • Nephrology
    • Virology

    Background:

    • The mesangial and reticuloendothelial systems play crucial roles in clearing immune complexes from circulation.
    • Immune complex glomerulonephritis, often caused by viral infections, can lead to kidney damage.
    • Lymphocytic choriomeningitis (LCM) virus infection in mice serves as a model for studying nephritis.

    Purpose of the Study:

    • To evaluate the function of the mesangial and reticuloendothelial systems in normal and LCM virus-infected mice with nephritis.
    • To investigate the mechanisms behind increased glomerular accumulation of immune complexes in nephritic mice.

    Main Methods:

    • Utilized heat-aggregated human immunoglobulin (AIgG) and colloidal carbon as traceable materials.
    • Administered AIgG via intraperitoneal (i.p.) injection and colloidal carbon/AIgG via intravenous (i.v.) injection.

    Related Experiment Videos

  • Compared the accumulation and removal rates of these materials in normal, LCM-infected nonproteinuric (LCM), and LCM-infected proteinuric (LCM-P) mice.

    • Main Results:

    • LCM-P mice exhibited greater glomerular accumulation of AIgG compared to normal or LCM mice.
    • The mesangial clearing system function was unimpaired in LCM-P mice, as indicated by normal AIgG removal rates from the kidney.
    • Reticuloendothelial system function was deficient in LCM-P mice, showing slower blood clearance rates for AIgG and colloidal carbon.

    Conclusions:

    • Increased glomerular accumulation of immune complexes in LCM-induced nephritis is not due to impaired mesangial clearance.
    • Deficient reticuloendothelial system clearance of blood-borne immune complex-like material contributes to glomerular deposition in nephritic animals.
    • This impaired clearance is a potential factor in the pathogenesis of immune complex glomerulonephritis in this model.