Prevalence and associations of gout and hyperuricaemia: results from an Australian population-based study
1Department of Rheumatology, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.
Insights
Gout affects 5.2% and hyperuricaemia 16.6% of South Australians, with higher rates in males. Optimal diagnosis and management of gout are crucial in Australia.
Area of Science:
- Epidemiology
- Public Health
- Rheumatology
Background:
- Gout and hyperuricaemia are significant global health concerns.
- A knowledge gap exists regarding their prevalence and impact within the Australian community.
- Understanding these conditions in Australia is vital for public health initiatives.
Purpose of the Study:
- To determine the prevalence of self-reported medically diagnosed gout in an Australian population.
- To ascertain the prevalence of hyperuricaemia in the same cohort.
- To identify associations between gout, hyperuricaemia, and various demographic and clinical factors.
Main Methods:
- Utilized data from the North West Adelaide Health Study, a longitudinal cohort.
- Collected data via questionnaires, clinical assessments, and telephone interviews.
- Defined gout by self-report or gout-specific medication; hyperuricaemia by serum uric acid levels.
Main Results:
- Gout prevalence was 5.2%, significantly higher in males (8.5%) than females (2.1%).
- Hyperuricaemia prevalence was 16.6%, with males also showing higher rates (17.8%).
- Both conditions were associated with male sex, higher BMI, and renal disease; no impact on quality of life (SF-36) was found.
Conclusions:
- Gout and hyperuricaemia exhibit high prevalence in the South Australian population.
- The findings underscore the necessity for improved diagnosis and management strategies for gout in Australia.
- Further research into the long-term impacts and optimal treatment of these conditions is warranted.
Background:
Despite gout and hyperuricaemia being major comorbid health issues worldwide, there is a knowledge gap regarding their impact in the Australian community.
Aims:
To determine the prevalence and associations of self-reported medically diagnosed gout and hyperuricaemia in an Australian population-based cohort.
Methods:
The North West Adelaide Health Study is a longitudinal cohort study consisting of three stages of data collection. Each stage comprised a self-complete questionnaire, clinic assessment and computer-assisted telephone interview. In Stage 3 (2008-2010), participants were asked if a doctor had ever diagnosed them with gout. Additional data included demographics, comorbidities, laboratory data and Short Form 36 (SF-36). Participants were defined as having gout if they had self-reported medically diagnosed gout or were taking any gout-specific medication (allopurinol, colchicine, probenecid). Hyperuricaemia was defined as a serum uric acid (SUA) level >0.42 mmol/L in men and >0.34 mmol/L in women.
Results:
The overall prevalence of gout was 5.2%. Males were significantly more likely to have gout than females (8.5 vs 2.1%, P < 0.001). The overall prevalence of hyperuricaemia was 16.6%, with being male again identified as a significant risk factor (17.8 vs 15.4%, P < 0.01). Both gout and hyperuricaemia were associated with male sex, body mass index and renal disease after multivariable adjustment. There was no significant difference reported in quality of life (mean SF-36) scores in participants with gout compared to unaffected individuals.
Conclusion:
The prevalence of gout and hyperuricaemia is high in the South Australian population. This study emphasises the need for optimal diagnosis and management of gout in Australia.
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