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Related Experiment Videos

Gene expression during Drosophila wing morphogenesis and differentiation.

Nan Ren1, Chunming Zhu, Haeryun Lee

  • 1Biology Department, Cancer Center and Morphogenesis and Regenerative Medicine Institute, University of Virginia, Charlottesville, 22903, USA.

Genetics
|July 7, 2005
PubMed
Summary

Researchers identified genes involved in Drosophila wing hair development. This study provides a valuable dataset for understanding morphogenesis, cuticle synthesis, and planar polarity.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • The Drosophila wing is a model system for studying planar cell polarity and morphogenesis.
  • Understanding gene function in wing hair development is crucial.

Purpose of the Study:

  • To identify candidate genes involved in Drosophila wing hair morphogenesis through a gene expression screen.
  • To functionally validate identified genes by examining their role in wing development.

Main Methods:

  • Gene expression profiling of pupal Drosophila wings at different stages of hair growth using Affymetrix gene chips.
  • Functional validation of candidate genes by analyzing wing phenotypes in mutants.

Main Results:

  • Identified 435 genes with at least fivefold expression change and 1335 genes with at least twofold change during hair growth.

Related Experiment Videos

  • Functional validation confirmed wing phenotypes for 9 out of 10 tested genes, including defects in hair initiation, maturation, cuticle formation, pigmentation, and polarity.

    • Conclusions:

    • The gene expression screen successfully identified numerous candidate genes regulating Drosophila wing hair morphogenesis.
    • The validated gene set provides a valuable resource for future research on hair development, cuticle synthesis, and planar polarity.