Related Experiment Video
Updated: Aug 17, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Warthin tumor-like variant of papillary thyroid carcinoma: a case with dedifferentiation (anaplastic changes) and
King Yin Lam1, Chung Yau Lo, William I Wei
1Discipline of Pathology, School of Medicine, Griffith University, Gold Coast, Australia. a.lam@griffith.edu.au
Abstract:
Warthin tumor-like variant of papillary thyroid carcinoma is uncommon and approx 80 cases have been reported in the literature. This tumor is often associated with a favorable prognosis. In this report, a Warthin tumor-like variant of the papillary thyroid carcinoma, 5-cm in maximum dimension, underwent anaplastic changes in a 74-yr-old woman. The tumor was positive for CD15 and EMA, and a high proliferative index was noted in the anaplastic area. The patient developed distant metastases after operation and died of the disease 18 mo after the operation. The present case is the first reported case of Warthin tumor-like variant of papillary thyroid carcinoma with anaplastic changes.
Related Concept Videos
Hyperthyroidism I: Introduction
Graves Disease II: Pathophysiology
Hyperthyroidism II: Pathophysiology
Cellular Adaptation IV: Dysplasia and Metaplasia
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Abnormal Proliferation

