Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

4.4K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thyroidectomy for Papillary Thyroid Carcinoma.

Methods in molecular biology (Clifton, N.J.)·2022
Same author

VEGF-A/VEGF-B/VEGF-C expressions in non-hereditary, non-metastatic phaeochromocytoma.

Histology and histopathology·2021
Same author

Factors affecting the approaches and complications of surgery in childhood papillary thyroid carcinomas.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2019
Same author

Impact of routine unilateral central neck dissection on preablative and postablative stimulated thyroglobulin levels after total thyroidectomy in papillary thyroid carcinoma.

Annals of surgical oncology·2011
Same author

Quantitative analysis of the expression of TGF-alpha and EGFR in papillary thyroid carcinoma: clinicopathological relevance.

Pathology·2011
Same author

Early prediction of hypocalcemia after thyroidectomy using parathyroid hormone: an analysis of pooled individual patient data from nine observational studies.

Journal of the American College of Surgeons·2007
Same journal

Tracking Synthetic Adhesins on Bacterial Surfaces with Immunofluorescence Microscopy.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Post-Selection Methods for Analyzing mRNA Display Selections and Optimization of Hits.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

High-Performance Computing in Tandem Mass Spectrometry (MS/MS) Peptide Identification.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Engineering and Adapting Disulfide-Containing Proteins to Enable Intracellular Functionality.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

AI-Driven Protein Research: From Prediction to Design.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Methods for the In Vitro Selection of Protein and Peptide Libraries Using mRNA Display.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Related Experiment Video

Updated: Sep 20, 2025

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

965

Lymph Node Dissection for Papillary Thyroid Carcinoma.

Chung Yau Lo1

  • 1Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong. cylo@hku.hk.

Methods in Molecular Biology (Clifton, N.J.)
|June 7, 2022
PubMed
Summary
This summary is machine-generated.

Cervical lymph node metastasis is common in papillary thyroid cancer. While therapeutic dissection of involved nodes is crucial, routine prophylactic neck dissection is generally not recommended due to limited benefits and potential complications.

Keywords:
Central neck dissectionExcision of lymph nodeLymph node metastasisPapillary thyroid carcinomaPostoperative complicationsSelective neck dissectionSurgical technique

More Related Videos

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
05:12

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

3.9K
Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach
05:10

Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach

Published on: September 15, 2023

1.1K

Related Experiment Videos

Last Updated: Sep 20, 2025

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

965
Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
05:12

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

3.9K
Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach
05:10

Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach

Published on: September 15, 2023

1.1K

Area of Science:

  • Oncology
  • Surgical Oncology
  • Head and Neck Surgery

Background:

  • Cervical lymph node metastasis is frequent in papillary thyroid carcinoma.
  • The extent of thyroidectomy and lymphadenectomy remains debated.
  • Metastasis commonly occurs in the central compartment, followed by the lateral compartment, with potential for skip metastasis.

Purpose of the Study:

  • To evaluate the role and extent of lymphadenectomy in managing papillary thyroid carcinoma with cervical lymph node metastasis.
  • To clarify the indications for prophylactic versus therapeutic neck dissection.
  • To assess the impact of routine central compartment dissection on recurrence and adjuvant therapy.

Main Methods:

  • Review of existing literature and clinical guidelines on thyroid cancer management.
  • Analysis of outcomes related to different surgical approaches for lymphadenectomy.
  • Evaluation of the accuracy of preoperative imaging for microscopic nodal disease.

Main Results:

  • Therapeutic lymph node dissection for clinically involved nodes is mandatory.
  • Routine prophylactic central compartment dissection is not recommended for all patients, particularly for low-risk tumors.
  • Prophylactic lateral neck dissection is contraindicated.
  • De-escalation of neck dissection and compartmental approaches aim to preserve function while ensuring complete resection.

Conclusions:

  • Surgical removal of clinically evident nodal metastasis is essential for papillary thyroid carcinoma.
  • Routine prophylactic central neck dissection should be reserved for high-risk cases.
  • Compartmental nodal dissection prioritizes functional preservation and complete resection.
  • Adjuvant radioiodine is often used for intermediate-risk patients with nodal metastasis.