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Published on: December 15, 2011
Pyoderma gangraenosum associated with autoimmune thyreopathy and hyperandrogenic syndrome
Miroslav Necas1, Vera Semrádova, Vladimír Vaskù
1Dept. of Dermatovenereology, St. Ann's Faculty Hospital, Pekarská 53, 656 91 Brno,Czech Republic.
Abstract:
An unusual clinical appearance and course of pyoderma gangraenosum (PG) in a 35-year-old woman is presented. Signs of both the ulcerative and vegetative forms of PG were expressed. The association of two systemic diseases, the autoimmune thyreopathy and the hyperandrogenic syndrome were observed in a female. The recommended conventional therapy for PG: corticosteroids, antibiotics, cyclosporine and cyclophosphamide yielded a poor response, whereas after thyroidectomy and reaching an euthyroid state the symptoms receded. This close association of PG and autoimmune thyreopathy supports the autoimmune concept of PG.
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