Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inhalational nickel carbonyl poisoning in waste processing workers.

Raymond C S Seet1, Azman Johan, Cuthbert E S Teo

  • 1Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074. raymond_seet@nus.edu.sg

Chest
|July 9, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multicenter retrospective cohort study showing that bridging thrombolysis does not achieve better outcomes compared to direct mechanical thrombectomy in stroke due to internal carotid artery occlusion.

Neuroradiology·2026
Same author

Subgroup analysis of genotype guided vs traditional warfarin dosing in Asian patients from an open label randomized trial.

Scientific reports·2026
Same author

Differentially Expressed Genes and Biological Pathways in Moyamoya Disease: A Systematic Review and Meta-analysis of Transcriptomic Studies.

Translational stroke research·2025
Same author

Left Ventricular Diastolic Dysfunction Is Associated with Poor Functional Outcomes after Endovascular Thrombectomy.

Journal of cardiovascular development and disease·2024
Same author

Low HALP (Hemoglobin, Albumin, Lymphocyte, and Platelet) Score Increases the Risk of Post-Stroke Cognitive Impairment: A Multicenter Cohort Study.

Clinical interventions in aging·2024
Same author

Estimated Incidence and Mortality of Stroke in China.

JAMA network open·2023

Acute nickel carbonyl poisoning is a severe occupational hazard, often fatal, particularly in subacute cases. Early identification and understanding of its toxic effects are crucial for patient outcomes.

Area of Science:

  • Occupational toxicology
  • Environmental health
  • Pulmonary medicine

Background:

  • Nickel carbonyl (Ni(CO)4) is a volatile and highly toxic compound formed from nickel and carbon monoxide.
  • Inhalation leads to rapid absorption and systemic distribution, primarily affecting the lungs, brain, adrenal glands, and kidneys.
  • Severe acute exposure can be rapidly fatal.

Observation:

  • A descriptive study of seven young men with symptoms including fever, chills, chest pain, and dyspnea following suspected nickel carbonyl exposure.
  • Clinical and autopsy findings revealed pulmonary consolidation, edema, hemorrhage, and fibrosis.
  • Elevated urinary nickel concentrations confirmed exposure, while microbiological investigations were negative for common pathogens.

Findings:

  • An unidentified chemical used in nickel waste neutralization was identified as the likely source of exposure.

Related Experiment Videos

  • Four patients required intensive care unit (ICU) treatment.
  • Autopsy findings in three deceased patients demonstrated severe lung damage.

    • Implications:

    • Subacute nickel carbonyl exposure is associated with high mortality.
    • Further research is needed to evaluate the efficacy of chelation therapy in managing subacute nickel carbonyl poisoning.
    • This study highlights the critical need for stringent safety protocols in industries handling nickel and carbon monoxide.