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Antiphospholipid syndrome: review

Lisa R Sammaritano1

  • 1Weill Medical College of Cornell University, Hospital of Special Surgery, New York, NY 10021, USA. sammaritan@hss.edu

Southern Medical Journal
|July 12, 2005
PubMed

Insights

Antiphospholipid syndrome involves antibodies and complications like blood clots or pregnancy loss. Treatment typically uses anticoagulation, but optimal intensity and duration remain under discussion.

Area of Science:

  • Internal Medicine
  • Rheumatology
  • Hematology

Background:

  • Antiphospholipid syndrome (APS) is a multisystem disorder.
  • Diagnostic criteria involve antiphospholipid antibodies and clinical events such as thrombosis or pregnancy morbidity.
  • Associated conditions include livedo reticularis, thrombocytopenia, and organ damage.

Purpose of the Study:

  • To review the clinical manifestations and diagnostic criteria of Antiphospholipid Syndrome.
  • To discuss current treatment strategies for APS complications.
  • To highlight areas of ongoing debate in APS management.

Main Methods:

  • Literature review of Antiphospholipid Syndrome.
  • Analysis of diagnostic criteria and clinical associations.
  • Summary of established and evolving treatment protocols.

Main Results:

  • APS is characterized by specific antibodies and a spectrum of clinical events.
  • Common manifestations include thrombosis, pregnancy loss, thrombocytopenia, and organ-specific damage.
  • Anticoagulation is the cornerstone of management for thrombotic events and pregnancy.

Conclusions:

  • Antiphospholipid syndrome requires multidisciplinary management.
  • Current treatments focus on anticoagulation, with ongoing research into optimal therapeutic strategies.
  • Further research is needed to refine anticoagulation protocols and address management controversies.

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