Related Experiment Video
Updated: Aug 17, 2026

Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
Published on: August 6, 2019
Novel synthesis and characterization of bioconjugate block copolymers having oligonucleotides
Atsushi Noro1, Yutaka Nagata, Masaki Tsukamoto
1Department of Applied Chemistry, Graduate School of Engineering, and Laboratory of Bioorganic Chemistry, Graduate School of Information Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
Abstract:
Novel and efficient synthesis of polymers terminated with nucleotides via the phosphoramidite method has been developed. A hydroxyl-terminated polymer was converted into a polymer capped with a nucleotide in three steps, where the conversion of the reactions was very high, almost 100%. By repetition of this synthetic method, a block copolymer composed of a synthetic polymer, polystyrene, and biological oligonucleotides with thymidine units has been successfully synthesized. A microphase-separated structure of this block copolymer was observed by both transmission electron microscopy and small-angle X-ray scattering, and a cylindrical structure was confirmed.
Related Concept Videos
Characteristics and Nomenclature of Copolymers
ATP and Macromolecule Synthesis
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
Nucleic Acid Structure
DNA Structure
DNA has a double-helix structure. The...
Site-Targeted Drug Delivery Systems: Polymeric Carriers

