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Horton's disease: past and present

Morris Levin1, Thomas N Ward

  • 1Section of Neurology, Dartmouth Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA. mo.levin@hitchcock.org

Current Pain and Headache Reports
|July 12, 2005
PubMed

Insights

Giant cell arteritis (GCA), also known as temporal arteritis or Horton's disease, can be challenging to diagnose and treat. Corticosteroid therapy remains the standard treatment, effectively managing symptoms and preventing complications.

Area of Science:

  • Rheumatology
  • Internal Medicine
  • Vascular Medicine

Background:

  • Giant cell arteritis (GCA), historically termed temporal arteritis or Horton's disease, has been recognized for centuries.
  • Hutchinson (1890) and Horton (1932) provided key characterizations in modern medical literature.
  • Despite its long history, GCA diagnosis remains elusive, and treatment presents challenges.

Observation:

  • Patients typically present with head pain and constitutional symptoms, particularly the elderly.
  • Prompt diagnosis is often achievable with careful clinical evaluation.
  • Corticosteroids have been the mainstay of treatment since the mid-1950s.

Findings:

  • Corticosteroid therapy is generally highly effective in alleviating GCA symptoms.
  • Treatment successfully relieves pain and tenderness.
  • Effective management prevents serious sequelae, including visual impairment.

Implications:

  • Understanding the historical evolution of GCA provides context for current medical approaches.
  • Knowledge of pathophysiology aids in refining diagnostic strategies.
  • Modern treatment options focus on optimizing corticosteroid efficacy and minimizing side effects.

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