Calcitonin gene-related peptide in the audiovestibular system

Area of Science:

• Neuroscience
• Ophthalmology
• Otolaryngology

Background:

• Calcitonin gene-related peptide (CGRP) is a neuropeptide linked to migraine.
• Vestibular migraine (VM) involves vertigo and migraine symptoms.
• CGRP's presence in the vestibular system suggests a role in VM.

Purpose of the Study:

• To review literature on CGRP, the vestibular system, and VM.
• To analyze CGRP's impact on vestibular function.

Main Methods:

• Literature synthesis of human and animal studies.
• Focused on CGRP neuroanatomy and vestibular system interactions.
• Included PubMed indexed research.

Main Results:

• CGRP found in rodent vestibular structures and efferent neurons.
• CGRP deficiency in mice impairs vestibular-ocular reflex and balance.
• CGRP infusion causes VM-like symptoms; antibodies reduce VM dizziness in humans.

Conclusions:

• CGRP is involved in the audiovestibular system and VM.
• CGRP-targeted therapies show potential for VM treatment.
• Further research is needed for CGRP's role in vestibular function and VM.