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Related Experiment Videos

Increased white matter hyperintensities in male methamphetamine abusers.

Soojeong C Bae1, In Kyoon Lyoo, Young Hoon Sung

  • 1Department of Psychiatry, Seoul National University College of Medicine and Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea.

Drug and Alcohol Dependence
|July 12, 2005
PubMed
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Methamphetamine abusers show increased white matter hyperintensities (WMH) on MRI scans compared to healthy individuals. Male abusers exhibit more severe WMH than females, potentially due to estrogen

Area of Science:

  • Neuroimaging
  • Neuroscience
  • Addiction Medicine

Background:

  • White matter signal hyperintensities (WMH) are indicators of brain injury.
  • Methamphetamine abuse is associated with various neurological complications.

Purpose of the Study:

  • To compare the prevalence, severity, and location of WMH in methamphetamine (MA) abusers versus healthy controls.
  • To investigate the relationship between MA use and WMH severity.

Main Methods:

  • 33 MA abusers and 32 healthy controls underwent 3.0 T brain MRI.
  • WMH severity was assessed for deep and periventricular regions.
  • Ordinal logistic regression analyzed odds ratios for WMH.

Main Results:

Related Experiment Videos

  • MA abusers showed significantly greater WMH severity than controls (ORs 7.06-8.46).
  • Deep WMH severity correlated with cumulative MA dose (p=0.027).
  • Male MA abusers had more severe WMH than females (OR=10.00) and male controls (OR=18.86).

    • Conclusions:

    • Increased WMH in MA abusers may stem from MA-induced cerebral perfusion deficits.
    • Estrogen might offer a protective effect in female MA abusers against MA's neurotoxic effects.