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Recent advances in small molecule drug delivery
Argaw Kidane1, Padmanabh P Bhatt
1Advanced Drug Delivery, Shire Laboratories, Inc., Rockville, Maryland, USA.
Current Opinion in Chemical Biology
|July 12, 2005
Summary
New drug delivery systems focus on advanced oral formulations beyond immediate-release tablets. These specialized products aim to overcome drug challenges and enhance patient treatment regimens.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Medicinal Chemistry
Background:
- Small molecule drugs represent the majority of pharmaceutical development.
- Oral administration via immediate-release tablets/capsules is the predominant drug delivery route.
- Existing oral dosage forms present physicochemical, physiological, and pharmacological challenges.
Purpose of the Study:
- To explore specialized drug delivery concepts for small molecule drugs.
- To improve upon traditional immediate-release oral formulations.
- To address inherent drug challenges and enhance patient treatment.
Main Methods:
- Development of advanced oral dosage forms.
- Application of rationalized drug delivery principles.
- Focus on overcoming drug-specific limitations.
Main Results:
- Specialized drug delivery concepts are increasingly incorporated into new drug products.
- These advanced formulations aim to mitigate drug-related challenges.
- Improved patient treatment regimens are a key outcome.
Conclusions:
- Advanced drug delivery systems offer significant advantages over traditional immediate-release formulations.
- Specialized oral drug products are crucial for optimizing small molecule drug therapy.
- The application of drug delivery concepts is expanding to initial product generations.