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Related Experiment Videos

Functional heartburn.

Ram Dickman1, Ronnie Fass

  • 1GI Section (1-111G-1), Southern Arizona VA Health Care System, 3601 South 6th Avenue, Tucson, Arizona 85723-0001, USA.

Current Treatment Options in Gastroenterology
|July 13, 2005
PubMed
Summary
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Functional heartburn (FH) affects many with nonerosive reflux disease. Treatment often requires potent acid suppression and may involve pain modulators for persistent symptoms.

Area of Science:

  • Gastroenterology
  • Digestive Health
  • Reflux Disorders

Background:

  • Functional heartburn (FH) represents 30-50% of nonerosive reflux disease cases.
  • FH encompasses heterogeneous patient groups, including hypersensitive and non-acid sensitive esophagus.
  • Underlying mechanisms, pain characteristics, and optimal treatments for FH require further elucidation.

Purpose of the Study:

  • To review the current understanding and therapeutic approaches for functional heartburn.
  • To highlight the challenges in treating FH, particularly proton pump inhibitor (PPI) non-responders.
  • To discuss potential future treatment modalities for FH.

Main Methods:

  • Literature review of functional heartburn pathophysiology and treatment.
  • Analysis of treatment responses in FH patients compared to other gastroesophageal reflux disease (GERD) groups.

Related Experiment Videos

  • Evaluation of current and emerging therapeutic strategies for FH.

    • Main Results:

    • FH patients show lower response rates to standard antireflux treatments compared to other GERD groups.
    • Proton pump inhibitors (PPIs) are recommended early, with dose escalation often necessary.
    • For PPI non-responders, adding pain modulators or visceral analgesics is a key therapeutic step.

    Conclusions:

    • Functional heartburn management requires a tailored approach, often involving potent acid suppression.
    • Escalating PPI dosage and incorporating pain modulators are crucial for refractory cases.
    • Further research into novel pain modulators and advanced antireflux medications is needed for FH.