Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rotational behavior as a classically conditioned response to pentobarbital administration.

P B Silverman1, J Grabowski, K E Lane

  • 1Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston 77030-3419.

European Journal of Pharmacology
|March 3, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Optimal omegas.

Frontiers in nutrition·2025
Same author

The Effect of Carbohydrate Restriction on Lipids, Lipoproteins, and Nuclear Magnetic Resonance-Based Metabolites: CALIBER, a Randomised Parallel Trial.

Nutrients·2023
Same author

Bupropion and naltrexone for smoking cessation: A double-blind randomized placebo-controlled clinical trial.

Clinical pharmacology and therapeutics·2016
Same author

Omega-3 fatty acids - A review of existing and innovative delivery methods.

Critical reviews in food science and nutrition·2015
Same author

Early life insult from cigarette smoke may be predictive of chronic diseases later in life.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals·2009
Same author

Radiation treatment planning in brain tumours: potential impact of 3-O-methyl-6-[(18)F]fluoro-L-DOPA and PET.

Nuklearmedizin. Nuclear medicine·2008

Rats with substantia nigra lesions learned to rotate in response to pentobarbital. This conditioned behavior persisted for at least 15 weeks, demonstrating long-term stimulus control.

Area of Science:

  • Neuroscience
  • Behavioral Pharmacology
  • Neuroscience Research

Background:

  • Unilateral 6-hydroxydopamine lesions of the substantia nigra induce rotational behavior in rats.
  • Investigating stimulus control of behavior is crucial for understanding neural pathways and drug effects.

Purpose of the Study:

  • To investigate pentobarbital's stimulus control over rotational behavior in rats with unilateral substantia nigra lesions.
  • To assess the persistence of conditioned rotational behavior.

Main Methods:

  • Rats with substantia nigra lesions underwent conditioning trials involving simultaneous injections of pentobarbital and apomorphine.
  • Rotational behavior was measured after administration of saline, pentobarbital, ethanol, and chlordiazepoxide.
  • Behavioral persistence was tested 15 weeks post-conditioning.

Related Experiment Videos

Main Results:

  • Pentobarbital, but not saline, elicited contralateral rotation after conditioning.
  • Chlordiazepoxide also induced rotation, while ethanol did not.
  • Conditioned rotation persisted for at least 15 weeks after the last conditioning session.

Conclusions:

  • Pentobarbital acts as a conditioned stimulus for rotational behavior in lesioned rats.
  • The conditioned response is specific and long-lasting.
  • This model provides insights into drug-induced behaviors and stimulus control in the central nervous system.