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Three new sesquiterpene hemiacetals from Achillea vermicularis
Viqar-Uddin Ahmad1, Umar Farooq, Javid Hussain
1International Center of Science, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. vuahmad@cyber.net.pk
Abstract:
Three new sesquiterpene hemiacetals, tentatively named as achilleanone (1), vermiculone (2) and vermicularone (3) have been isolated from Achillea vermicularis, along with three other known compounds beta-amyrin, oleonolic acid and beta-sitosterol. The structure elucidation of new compounds was based primarily on two-dimensional (2D) NMR techniques including Nuclear Overhauser Effect/Enhancement (NOE), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC) and nuclear overhauser effect spectroscopy (NOESY) experiments. Compounds 1, 2 and 3 have displayed inhibitory potential against lipoxygenase enzyme in a concentration-dependent fashion with promising IC50 values.
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