Related Experiment Video
Updated: Jul 12, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
[Experimental study on treatment of minimal change nephropathy with Lespedeza michx]
Cai-Yun Wang1, Hong-Zhu Deng, Hui Li
1Traditional Chinese Medicine Department, First Military Medical University, Guangzhou 510515, China.
Objective:
To study the therapeutic effect of Lespedeza Michx in experimental rat model of minimal change nephropathy (MCN).
Method:
The rat MCN model was reproduced by tail-intravenous injection of Adriamycin. The treatment effect of Lespedeza Michx was determined by the detection of urine protein collection for 24 hours, malondialdehyde (MDA), superoxide dismutase (SOD), ATCO, IL-8, TNF-alpha in serum, and renal histopathological changes were observed by microscope.
Result:
Lespedeza Michx could decrease the contents of urine proteinuria, MDA, IL-8, and TNF-alpha in serum, increase SOD level and improved the pathological change of glomeruli.
Conclusion:
Lespedeza Michx was effective on MCN.
Related Concept Videos
Heart Failure V: Medical Management
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome II : Assessment and Medical Management
Nephrotic Syndrome III : Nursing Management

