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Updated: Aug 17, 2026

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
Published on: February 28, 2012
[Long-lasting survival of patients with implantable cardioverter-defibrillators implanted for secondary preventive
M Kozák1, M Sepsi, J Vlasínová
1Interní kardiologická klinika FN, Brno. kozak.milan@post.cz
Insights
Implantable cardioverter-defibrillator (ICD) therapy outcomes are worse for patients with coronary artery disease, especially when revascularization is not possible before ICD implantation. Terminal heart failure, not sudden death, was the primary cause of mortality in this long-term study.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Device Therapy
Context:
- Effectiveness of implantable cardioverter-defibrillators (ICDs) is typically assessed by overall patient mortality.
- Long-term outcomes and mortality patterns in ICD recipients require ongoing investigation.
- Understanding the impact of specific diagnoses and interventions on ICD patient survival is crucial.
Purpose:
- To analyze the long-term total mortality of patients receiving implantable cardioverter-defibrillators (ICDs).
- To evaluate mortality rates based on primary cardiac diagnoses in ICD patients.
- To assess the influence of revascularization procedures on mortality in patients with coronary artery disease (CAD) who have ICDs.
Summary:
- This study followed 138 patients with ICDs for malignant ventricular arrhythmias, observing a 22% overall mortality rate over a mean of 47.35 months.
- Terminal heart failure was the predominant cause of death (84%), with no sudden cardiac deaths recorded.
- Patients with coronary artery disease (CAD) exhibited higher mortality (27%), particularly those ineligible for pre-ICD revascularization (38% vs. 20%).
Impact:
- ICD patient survival is significantly reduced when coronary artery disease is present and revascularization is not feasible prior to implantation.
- Findings highlight the importance of considering revascularization status in risk stratification for ICD patients with CAD.
- The study underscores that terminal heart failure is a major concern in long-term ICD therapy, necessitating tailored management strategies.
Background:
The effectiveness of therapy with implantable cardioverter-defibrillators is usually evaluated according to the total mortality of ICD patients. The aim of this study is to analyse the total mortality of long-term followed ICD patients and to evaluate mortality according to the main diagnosis and analyse the influence of revascularization in patients with coronary artery disease.
Methods And Results:
We have observed 138 consecutive patients in mean age of 62.0+/-12.2 year (108 M, 30 F) with mean LVEF 0.38+/-0.14, who had ICD implanted for malignant ventricular arrhythmias from X/95 to XII/02 from secondary preventive reasons. The mean follow-up was 47.35 months. 99 patients had coronary artery disease, 16 dilated cardiomyopathy, 5 right ventricle dysplazia, 4 LQT syndrome, 1 valvular disease and 13 pts were without structural heart disease. The total mortality of the group of patients was 22% (31 patients). The terminal heart failure was the main cause of death in our pts--in 84% of the cases. We had no sudden death in our group of pts. The highest mortality (27%) was in pts with coronary artery disease, nobody died in the group of pts without structural heart disease. The higher mortality was in patients in pts where the revascularization was not possible before ICD implantation (38% versus 20%) One-year survival of the whole group of pts covered 90% and two-year survival was 87%.
Conclusions:
The survival of ICD pts is shorter if coronary artery disease is present and there is no possibility to revascularize pts before ICD implantation.
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