[Long-lasting survival of patients with implantable cardioverter-defibrillators implanted for secondary preventive

M Kozák1, M Sepsi, J Vlasínová

  • 1Interní kardiologická klinika FN, Brno. kozak.milan@post.cz

Insights

Implantable cardioverter-defibrillator (ICD) therapy outcomes are worse for patients with coronary artery disease, especially when revascularization is not possible before ICD implantation. Terminal heart failure, not sudden death, was the primary cause of mortality in this long-term study.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Device Therapy

Context:

  • Effectiveness of implantable cardioverter-defibrillators (ICDs) is typically assessed by overall patient mortality.
  • Long-term outcomes and mortality patterns in ICD recipients require ongoing investigation.
  • Understanding the impact of specific diagnoses and interventions on ICD patient survival is crucial.

Purpose:

  • To analyze the long-term total mortality of patients receiving implantable cardioverter-defibrillators (ICDs).
  • To evaluate mortality rates based on primary cardiac diagnoses in ICD patients.
  • To assess the influence of revascularization procedures on mortality in patients with coronary artery disease (CAD) who have ICDs.

Summary:

  • This study followed 138 patients with ICDs for malignant ventricular arrhythmias, observing a 22% overall mortality rate over a mean of 47.35 months.
  • Terminal heart failure was the predominant cause of death (84%), with no sudden cardiac deaths recorded.
  • Patients with coronary artery disease (CAD) exhibited higher mortality (27%), particularly those ineligible for pre-ICD revascularization (38% vs. 20%).

Impact:

  • ICD patient survival is significantly reduced when coronary artery disease is present and revascularization is not feasible prior to implantation.
  • Findings highlight the importance of considering revascularization status in risk stratification for ICD patients with CAD.
  • The study underscores that terminal heart failure is a major concern in long-term ICD therapy, necessitating tailored management strategies.
Abstract

Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Cardiopulmonary Resuscitation III: AED Use01:23

Cardiopulmonary Resuscitation III: AED Use

Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...