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Related Experiment Videos

Surgical glove-associated diffuse lamellar keratitis.

Richard S Hoffman1, I Howard Fine, Mark Packer

  • 1Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA. rshoffman@finemd.com

Cornea
|July 15, 2005
PubMed
Summary

Silicone oil contamination on surgical gloves was identified as a cause of diffuse lamellar keratitis (DLK) outbreaks. Changing glove brands eliminated the epidemic, highlighting glove contamination as a key factor in DLK.

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Area of Science:

  • Ophthalmology
  • Materials Science

Background:

  • Diffuse lamellar keratitis (DLK) is an inflammatory condition affecting the cornea.
  • Prolonged DLK epidemics can significantly impact surgical center patient outcomes.

Purpose of the Study:

  • To investigate the cause of a multi-year epidemic of diffuse lamellar keratitis (DLK).
  • To identify potential contaminants on surgical gloves linked to DLK outbreaks.

Main Methods:

  • Retrospective analysis of DLK incidence over three years.
  • Comparison of surgical glove brands using optical microscopy, SEM-EDS, and FTIR spectroscopy.
  • Correlation of glove brand with DLK epidemic occurrence.

Main Results:

  • DLK incidence varied from 2% to 38% quarterly during the epidemic.

Related Experiment Videos

  • Switching surgical glove brands led to the cessation of DLK cases.
  • DLK-associated gloves showed extensive silicone oil contamination, unlike the control gloves.

    • Conclusions:

    • Silicone oil contamination on surgical gloves is strongly associated with epidemic diffuse lamellar keratitis.
    • Surgical glove selection and quality control are critical for preventing DLK outbreaks.