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Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
09:44

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss

Published on: January 25, 2016

The role of factor V Leiden and prothrombin G20210A mutations in sudden sensorineural hearing loss

Kemal Görür1, Ulkü Tuncer, Gülçin Eskandari

  • 1Department of Otorhinolaryngology, University of Mersin School of Medicine, Mersin, Turkey. kgorur@mersin.edu.tr

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology
|July 15, 2005
PubMed

Insights

Factor V Leiden mutation is linked to sudden sensorineural hearing loss (SSHL). This genetic risk factor was more prevalent in SSHL patients than controls, suggesting a potential role in the condition. Prothrombin G20210A showed no significant association.

Area of Science:

  • Genetics
  • Otolaryngology
  • Hematology

Background:

  • Sudden sensorineural hearing loss (SSHL) can result from microthromboangiopathy affecting cochlear blood supply.
  • Factor V Leiden and prothrombin G20210A mutations are known genetic risk factors for thrombotic microangiopathy.

Purpose of the Study:

  • To investigate the incidence of factor V Leiden and prothrombin G20210A mutations in patients with sudden sensorineural hearing loss (SSHL).

Main Methods:

  • A case-control study involving 56 SSHL patients and 95 controls.
  • Genomic DNA was analyzed for factor V Leiden and prothrombin G20210A mutations using polymerase chain reaction.

Main Results:

  • Factor V Leiden mutation was significantly more frequent in SSHL patients (16.1%) compared to controls (5.3%) (p=0.02).
  • No significant difference in prothrombin G20210A mutation incidence was observed between SSHL patients and controls.
  • All identified mutations were heterozygous.

Conclusions:

  • A significant association exists between factor V Leiden mutation and idiopathic SSHL.
  • Prothrombin G20210A mutation does not appear to correlate with the occurrence of idiopathic SSHL.
Abstract

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