[Interferon induction by lacticacid bacteria in vitro and in vivo experiments]

Interferonogenic acitivity of lacticacid bacteria was studied in experiments in vitro and in vivo. It have been shown, that interferon induction depends both on strain species and on culture medium used for lactobacteria harvesting. Streptococcus thermophilus induces interferon more actively in leucocytes (in vitro)--1280 AU/ml on the bines broth medium, and less actively--320 AU/ml on fermented corn medium. Interferon induction in human leucocytes was not registered in case of L. plantarum 200 strain. In vivo experiments show that E. faecium strain and strain mixture of streptococcus termophilus are active interferon inductors. Induced interferon is recognized as alpha- and gamma-interferon, with domination of alpha-interferon.