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Determination of microsphere solidification time in the solvent evaporation process.
T Mateović1, M Ratnik, M Bogataj
1Faculty of Pharmacy, University of Ljubljana, Slovenia.
Journal of Microencapsulation
|July 16, 2005
Summary
This study determined microsphere solidification times during solvent evaporation. Solidification occurred between 10-20 minutes, influenced by initial emulsion temperature and stirring rates, crucial for drug delivery formulation.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Microsphere formulation is key for controlled drug delivery.
- Understanding microsphere solidification is vital for reproducible drug release.
Purpose of the Study:
- To define the solidification time of microspheres during solvent evaporation.
- To investigate the influence of temperature and stirring rate on microsphere formation.
Main Methods:
- Solvent evaporation method using acetone/liquid paraffin, ketoprofen, and Eudragit RS.
- Experiments conducted at initial temperatures of 5°C and 25°C.
- Varied stirring rates (250, 1000 rpm) and dynamic rate changes to determine solidification endpoint.
Main Results:
- Microsphere solidification time ranged from 15-20 min at 5°C and 10-20 min at 25°C.
- Sieve analysis provided a reliable method for determining solidification time.
- Drug release profiles suggested slightly earlier solidification than sieve analysis indicated.
Conclusions:
- Solidification time is dependent on initial temperature and stirring dynamics.
- Sieve analysis is effective for determining microsphere solidification time.
- Further optimization of solvent evaporation parameters can enhance microsphere properties.