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Updated: Aug 17, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Multiple disseminated large-cell acanthomas of the skin associated with human papillomavirus type 6
Thomas Berger1, Eggert Stockfleth, Thomas Meyer
1Departments of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany. bergerts@web.de
Abstract:
Cutaneous acanthomas encompass many clinically distinct types. We describe a patient with multiple nodules on the skin of the upper limbs which were histologically diagnosed as large-cell acanthomas. Further analysis revealed, surprisingly, the presence of human papillomavirus (HPV) type 6 within these lesions. HPV type 6 should therefore be considered an important cofactor in the pathogenesis of large-cell acanthomas.
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