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Updated: Aug 17, 2026

Computerized Adaptive Testing System of Functional Assessment of Stroke
Published on: January 7, 2019
Statistical consideration of adaptive methods in clinical development
Shein-Chung Chow1, Mark Chang, Annpey Pong
1Division of Biostatistics and Bioinformatics, National Health Research Institutes, Taipei, Taiwan. schow@nhri.org.tw
Abstract:
In recent years, the use of adaptive methods in clinical development based on accrued data has become very popular due to its flexibility in modifying trial procedures and/or statistical procedures of on-going clinical trials. However, it is a concern that the actual patient population after the modifications could deviate from the originally targeted patient population. Major modifications of trial procedures and/or statistical procedures of on-going trials may result in a totally different trial, which is unable to address the scientific/medical questions that the trial intends to answer.
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