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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

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Joint linear and nonlinear mixed effects model with random change points for left-censored longitudinal data:

Binod Manandhar1, Hongbin Zhang2

  • 1Department of Mathematical Sciences, Clark Atlanta University, Atlanta, Georgia, USA.

Journal of Biopharmaceutical Statistics
|October 27, 2026
PubMed

Keywords:
Antiretroviral therapyMetropolis–Hastings samplercensored observationchange-pointlongitudinal datamixed effects modelstochastic approximation expectation maximization

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