Related Experiment Video
Updated: Aug 17, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
Risk factors for pediatric invasive group A streptococcal disease
Stephanie H Factor1, Orin S Levine, Lee H Harrison
1Centers for Disease Control and Prevention, Atlanta, Georgia, USA. sfactor@health.nyc.gov
Abstract:
Invasive group A Streptococcus (GAS) infections can be fatal and can occur in healthy children. A case-control study identified factors associated with pediatric disease. Case-patients were identified when Streptococcus pyogenes was isolated from a normally sterile site, and matched controls (>or=2) were identified by using sequential-digit dialing. All participants were noninstitutionalized surveillance-area residents <18 years of age. Conditional regression identified factors associated with invasive disease: other children living in the home (odds ratio [OR]=16.85, p=0.0002) and new use of nonsteroidal antiinflammatory drugs (OR=10.64, p=0.005) were associated with increased risk. More rooms in the home (OR=0.67, p=0.03) and household member(s) with runny nose (OR=0.09, p=0.002) were associated with decreased risk. Among children, household-level characteristics that influence exposure to GAS most affect development of invasive disease.
Related Concept Videos
Streptococcal Pharyngitis
Staphylococcal Skin Infections
Determinants of Bacterial Pathogenicity and Virulence
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Bacterial Meningitis I: Introduction
Tonsillitis I: Introduction
Etiology
Three primary contributing factors have been identified.