Molecular pharmaceutics: the NIH Roadmap and the FDA pipeline problem

A new model for ionizable drug dissolution in intestinal bicarbonate buffer.

Journal of pharmaceutical sciences·2025

Solubility vs Dissolution in Physiological Bicarbonate Buffer.

Pharmaceutical research·2024

Comparative Evaluation of Dissolution Performance in a USP 2 Setup and Alternative Stirrers and Vessel Designs: A Systematic Computational Investigation.

Molecular pharmaceutics·2024

Particle Size, Dose, and Confinement Affect Passive Diffusion Flux through the Membrane Concentration Boundary Layer.

Molecular pharmaceutics·2023

Physiological Dynamics in the Upper Gastrointestinal Tract and the Development of Gastrointestinal Absorption Models for the Immediate-Release Oral Dosage Forms in Healthy Adult Human.

Pharmaceutical research·2023

Stochastic Differential Equation-based Mixed Effects Model of the Fluid Volume in the Fasted Stomach in Healthy Adult Human.

The AAPS journal·2023

Fibroblast-Selective Lipid Nanoparticles for Tumor Stromal Transfection.

Molecular pharmaceutics·2026

Proof-of-Concept Development and Preclinical Evaluation of a Microarray Patch Platform for Codelivery of Multiple Broadly Neutralizing Antibodies for HIV Prevention.

Molecular pharmaceutics·2026

Improving Pharmacokinetics of PSMA/GRPR-Targeting Radiolabeled Heterodimer through Enhanced Albumin Binding.

Molecular pharmaceutics·2026

Evaluation of 161Tb-Labeled DOTA-Ibandronate for Targeted Radionuclide Therapy in Bone Metastases.

Molecular pharmaceutics·2026

Drug Delivery-Enabled Antibiofilm Therapeutics from Traditional Chinese Medicine-Derived Bioactives: Recent Advances and Future Perspectives.

Molecular pharmaceutics·2026

Radiolabeled Mesoporous Silica Nanosystem Enables Long-Term Cell Tracking In Vivo.

Molecular pharmaceutics·2026

Exploring the Distinct Regulatory Actions and Molecular Pathways of Coptisine Through Network Pharmacology: Insights Into Its Influence on Platelet Activation and Thrombus Development.

Food science & nutrition·2026

Effect of Betahistine on Daytime Sedation and Metabolic Parameters in Patients with Schizophrenia on Second-generation Antipsychotics.

Indian journal of psychological medicine·2026

Adult dual and polytobacco use in the United States: Findings from the 2021-2023 National Survey on Drug Use and Health.

Preventive medicine reports·2026

Dipeptidyl Peptidase-4 (DPP-4) Inhibitors Versus Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists Following Orthopedic Shoulder Surgery: A Comparative Analysis.

Cureus·2026

Dipeptidyl Peptidase-4 (DPP-4) Inhibitors Are Associated With Reduced Early but Increased Chronic Postoperative Opioid Use After Shoulder Surgery.

Cureus·2026

Simvastatin modulates sleep-wake behavior and locomotor activity in a dose-dependent manner in Drosophila.

Frontiers in pharmacology·2026

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Molecular pharmaceutics: the NIH Roadmap and the FDA pipeline problem

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A new model for ionizable drug dissolution in intestinal bicarbonate buffer.

Solubility vs Dissolution in Physiological Bicarbonate Buffer.

Comparative Evaluation of Dissolution Performance in a USP 2 Setup and Alternative Stirrers and Vessel Designs: A Systematic Computational Investigation.

Particle Size, Dose, and Confinement Affect Passive Diffusion Flux through the Membrane Concentration Boundary Layer.

Physiological Dynamics in the Upper Gastrointestinal Tract and the Development of Gastrointestinal Absorption Models for the Immediate-Release Oral Dosage Forms in Healthy Adult Human.

Stochastic Differential Equation-based Mixed Effects Model of the Fluid Volume in the Fasted Stomach in Healthy Adult Human.

Fibroblast-Selective Lipid Nanoparticles for Tumor Stromal Transfection.

Proof-of-Concept Development and Preclinical Evaluation of a Microarray Patch Platform for Codelivery of Multiple Broadly Neutralizing Antibodies for HIV Prevention.

Improving Pharmacokinetics of PSMA/GRPR-Targeting Radiolabeled Heterodimer through Enhanced Albumin Binding.

Evaluation of 161Tb-Labeled DOTA-Ibandronate for Targeted Radionuclide Therapy in Bone Metastases.

Drug Delivery-Enabled Antibiofilm Therapeutics from Traditional Chinese Medicine-Derived Bioactives: Recent Advances and Future Perspectives.

Radiolabeled Mesoporous Silica Nanosystem Enables Long-Term Cell Tracking In Vivo.

Exploring the Distinct Regulatory Actions and Molecular Pathways of Coptisine Through Network Pharmacology: Insights Into Its Influence on Platelet Activation and Thrombus Development.

Effect of Betahistine on Daytime Sedation and Metabolic Parameters in Patients with Schizophrenia on Second-generation Antipsychotics.

Adult dual and polytobacco use in the United States: Findings from the 2021-2023 National Survey on Drug Use and Health.

Dipeptidyl Peptidase-4 (DPP-4) Inhibitors Versus Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists Following Orthopedic Shoulder Surgery: A Comparative Analysis.

Dipeptidyl Peptidase-4 (DPP-4) Inhibitors Are Associated With Reduced Early but Increased Chronic Postoperative Opioid Use After Shoulder Surgery.

Simvastatin modulates sleep-wake behavior and locomotor activity in a dose-dependent manner in Drosophila.

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Molecular pharmaceutics: the NIH Roadmap and the FDA pipeline problem

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