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Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling
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Published on: October 27, 2023

Radiolabeled Mesoporous Silica Nanosystem Enables Long-Term Cell Tracking In Vivo.

Mengxin Xu1, Jiangsheng Li2, Jiaqi Li3

  • 1Beijing National Laboratory for Molecular Sciences, Cross-disciplinary Center for f-Elements (CCFE), Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.

Molecular Pharmaceutics
|July 13, 2026
PubMed
Summary

We developed zirconium-89 labeled mesoporous silica nanoparticles (89Zr-mSiO2) for precise cell tracking. This novel method enables reliable, long-term in vivo monitoring of functional cells using PET imaging.

Keywords:
PET imagingcell trackingmesoporous silica nanoparticleszirconium-89

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Area of Science:

  • Biomedical Engineering
  • Radiochemistry
  • Nanotechnology

Background:

  • Clinical cell therapy requires precise in vivo cell tracking.
  • Current methods face challenges in achieving reliable and long-term monitoring.
  • Advanced imaging techniques are crucial for therapeutic cell localization.

Purpose of the Study:

  • To introduce zirconium-89 labeled mesoporous silica nanoparticles (89Zr-mSiO2) as a novel platform for cell tracking.
  • To evaluate the biocompatibility, stability, and cell tracking capabilities of 89Zr-mSiO2.
  • To demonstrate the utility of 89Zr-mSiO2 for in vivo cell localization using PET imaging.

Main Methods:

  • Synthesis and characterization of 89Zr-mSiO2 nanoparticles.
  • In vitro assessment of nanoparticle biocompatibility, cellular uptake, and stability.
  • In vivo PET imaging studies in murine models to track labeled cells.

Main Results:

  • 89Zr-mSiO2 nanoparticles demonstrated excellent biocompatibility and high cellular internalization efficiency.
  • Prolonged stability and minimal cytotoxicity were observed in both in vitro and in vivo studies.
  • PET imaging enabled real-time tracking of 89Zr-mSiO2 labeled cells for up to 10 days with negligible cell efflux.

Conclusions:

  • 89Zr-mSiO2 provides a robust and safe platform for long-term in vivo cell tracking.
  • This technology facilitates precise monitoring of functional cells, crucial for advancing cell therapy.
  • 89Zr-mSiO2 holds significant promise for clinical applications in cell-based therapeutics.