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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Radiotherapy meets anticancer metallodrugs.

Shuren Zhang1, Siyong Shen2, Jiangsheng Li3

  • 1Changping Laboratory, Beijing, China.

Medical Review (2021)
|May 4, 2026
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Summary
This summary is machine-generated.

Radiotherapy and chemotherapy are enhanced by metallodrugs, with radiation activating metal compounds for targeted cancer treatment. This intersection improves tumor selectivity and synergistic control, advancing oncology therapies.

Keywords:
cancer therapychemoradiotherapymetallodrugsprecise medicineradiotherapy

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Area of Science:

  • Oncology
  • Radiochemistry
  • Materials Science

Background:

  • Combined radiotherapy and chemotherapy are standard cancer treatments.
  • Metallodrugs, particularly platinum agents, are crucial but face toxicity and selectivity issues.
  • Advances in radiation and metal chemistry enable new therapeutic strategies.

Purpose of the Study:

  • To explore the intersection of radiotherapy and metallodrugs.
  • To highlight how radiation can activate and modulate metallodrugs.
  • To discuss the potential for enhanced cancer treatment through this synergy.

Main Methods:

  • Reviewing strategies where radiation activates metallodrugs.
  • Examining platinum prodrugs, non-platinum metal complexes, and high-Z materials.
  • Discussing radiometal-based drugs integrating radiochemistry and coordination chemistry.

Main Results:

  • Ionizing radiation can activate, modulate, or amplify metallodrug function in tumors.
  • Radiation energy can achieve spatially confined cytotoxicity and immune modulation.
  • Synergistic tumor control is achievable through the integration of radiotherapy and metallodrugs.

Conclusions:

  • The combination of radiotherapy and metallodrugs offers enhanced, targeted cancer treatment.
  • Radiometal-based drugs represent a key development at the intersection of these therapies.
  • This integrated approach holds significant promise for clinical oncology.