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HTR2A: association and expression studies in neuropsychiatric genetics
Nadine Norton1, Michael J Owen
1Department of Psychological Medicine, Henry Wellcome Building, Wales School of Medicine, Heath Park, Cardiff CF14 4XN, UK. nortonn@cf.ac.uk
Annals of Medicine
|July 20, 2005
Summary
The serotonin 2A receptor gene (HTR2A) is linked to numerous neuropsychiatric disorders. This review synthesizes genetic and expression studies implicating HTR2A in conditions like schizophrenia and Alzheimer's disease.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- The 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) gene is a key focus in neuropsychiatric research.
- It has been associated with a wide range of conditions including schizophrenia, ADHD, affective and anxiety disorders, eating disorders, OCD, suicide, and Alzheimer's disease.
Purpose of the Study:
- To review and summarize existing research on the HTR2A gene's role in various neuropsychiatric phenotypes.
- To consolidate findings from genetic association, protein expression, and transcriptional expression studies.
Main Methods:
- Literature review of studies investigating HTR2A.
- Examination of genetic association studies (case-control, family-based).
- Analysis of protein expression (receptor binding assays) and mRNA expression data.
Main Results:
- The HTR2A gene has been implicated across a spectrum of neuropsychiatric disorders.
- Evidence spans genetic association, receptor binding, and mRNA expression levels.
- Consistent findings across diverse methodologies support HTR2A's functional relevance.
Conclusions:
- The HTR2A gene is a significant candidate gene for multiple neuropsychiatric conditions.
- Further research into HTR2A mechanisms is warranted for understanding and treating these disorders.
- This review highlights the broad impact of HTR2A on brain function and behavior.