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Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
12:29

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

Published on: May 30, 2011

Multislice continuous arterial spin-labeled perfusion MRI in patients with chronic occlusive cerebrovascular disease:

Hirohiko Kimura1, Hirotsugu Kado, Yoshio Koshimoto

  • 1Department of Radiology, Faculty of Medical Science, University of Fukui, 23 Shimoaizuki, Yoshida-gun, Katsukoa-cho, Fukui 910-1193, Japan. kimura@fmsrsa.fukui-med.ac.jp

Journal of Magnetic Resonance Imaging : JMRI
|July 20, 2005
PubMed

Insights

Continuous arterial spin labeling (CASL) provides feasible cerebral blood flow (CBF) quantification in cerebrovascular disease. However, longer transit times may underestimate CBF in affected areas.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Chronic occlusive cerebrovascular disease presents altered hemodynamic states.
  • Accurate assessment of cerebral blood flow (CBF) is crucial for managing these conditions.

Purpose of the Study:

  • To validate quantitative continuous arterial spin labeling (CASL) for CBF measurement in patients with cerebrovascular disease.
  • To compare CASL with positron emission tomography (PET) in an altered hemodynamic state.

Main Methods:

  • Eleven patients with occlusive carotid artery disease underwent multislice CASL and conventional MRI.
  • Cerebral blood flow (CBF) was measured using O(15)-labeled CO(2) gas with whole-body PET.
  • Linear regression analysis compared CBF values from coregistered CASL and PET images.

Main Results:

  • A significant correlation (r = 0.71 +/- 0.07, P < 0.001) was observed between CASL and PET CBF values.
  • Regression line slopes varied significantly (0.54-1.77) among patients.
  • Longer transit times were detected in hypoperfusion regions in four patients.

Conclusions:

  • Quantitative CBF measurement using CASL is feasible in routine clinical settings.
  • CASL offers a reasonable approach for assessing perfusion in cerebrovascular disease.
  • Transit time effects can lead to underestimation of CBF on the affected side in occlusive cerebrovascular disease.
Abstract

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