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Eruptive epidermoid cysts resulting from treatment with imiquimod
Chelsy L Marty1, Henry W Randle, John S Walsh
1Department of Dermatology, Mayo Clinic, Jacksonville, FL 32224, USA.
Background:
Because of its unique mechanism of action and safety profile, imiquimod, a topical immune response modifier, is used for many benign and malignant dermatologic conditions. Adverse effects are typically limited to treatment site erythema and erosion.
Objective:
To describe a newly recognized adverse effect of imiquimod.
Methods:
A 79-year-old woman being treated with imiquimod 5 days per week for a nodular basal cell developed a verrucous plaque over the treatment area after 7 weeks of therapy.
Results:
Scouting biopsies demonstrated multiple comedones and ruptured epidermoid cysts. There was no evidence of residual basal cell carcinoma.
Conclusions:
Imiquimod is a new and novel treatment option for cutaneous malignancies. We report its successful use in the treatment of a nodular basal cell carcinoma. The multiple comedones and ruptured epidermoid cysts are newly reported adverse effects of imiquimod therapy.
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