Related Experiment Videos
Familial progressive nephropathy in young Bull Terriers.
B R Jones1, M A Gething, L M Badcoe
1Department of Veterinary Clinical Sciences, Massey University, Palmerston North.
New Zealand Veterinary Journal
|June 1, 1989
Summary
Three young Bull Terriers experienced advanced kidney disease, characterized by anorexia, lethargy, and polydipsia. The condition, likely inherited, involves significant kidney damage and may be familial.
Area of Science:
- Veterinary Medicine
- Canine Pathology
- Nephrology
Background:
- Advanced renal disease can affect young dogs, presenting with non-specific clinical signs.
- Bull Terriers may be predisposed to certain inherited kidney conditions.
Purpose of the Study:
- To describe the clinical, clinicopathological, and pathological findings in three young Bull Terriers with advanced renal disease.
- To compare these findings with previously reported cases in Bull Terriers.
Main Methods:
- Case series describing clinical presentation, clinicopathological data (including azotemia, isosthenuria, and proteinuria), and post-mortem necropsy and histological findings.
- Histological examination focused on assessing nephron loss, glomerular atrophy, interstitial fibrosis, and basement membrane mineralization.
Main Results:
- Three Bull Terriers under four years old presented with anorexia, lethargy, and polydipsia.
- All dogs were azotemic and isosthenuric; two were proteinuric.
- Necropsy revealed shrunken kidneys with histological evidence of nephron loss, glomerular atrophy, interstitial fibrosis, and mineralization.
Conclusions:
- The described progressive renal disease in these Bull Terriers shares similarities with previously reported cases.
- The condition is likely familial and inherited, suggesting a genetic predisposition in the breed.