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Published on: October 12, 2012
Polyglucosan body disease in a mixed-breed dog
R D Jolly1, F I Hill, J A Hill
1Institute of Veterinary Animal and Biomedical Sciences, Massey University, Private Bag 11222, Palmerston North, New Zealand. R.D.Jolly@massey.ac.nz
Aim:
To describe the histopathology of a previously unrecorded canine disease and deduce the cause of the lesions.
Methods:
Formalin-fixed tissues were processed into paraffin wax and epoxy resin for light and electron microscopy of variously stained sections of liver, brain, heart muscle and kidney.
Results:
Periodic acid Schiff (PAS) -positive bodies in liver and myocardium were typical of a polyglucosan body disease. Neurons contained coarse granular material that stained similarly to the polyglucosan bodies.
Conclusion:
The nature, distribution and histochemistry of lesions observed are consistent with a putative diagnosis of Glycogen storage disease type IV, an inherited metabolic defect associated with a deficiency of glycogen-branching enzyme not previously reported in dogs.
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