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Polyglucosan body disease in a mixed-breed dog
R D Jolly1, F I Hill, J A Hill
1Institute of Veterinary Animal and Biomedical Sciences, Massey University, Private Bag 11222, Palmerston North, New Zealand. R.D.Jolly@massey.ac.nz
New Zealand Veterinary Journal
|July 21, 2005
Summary
A new canine disease, likely Glycogen storage disease type IV, was identified. This inherited metabolic defect involves polyglucosan bodies in organs and neurons, caused by glycogen-branching enzyme deficiency.
Area of Science:
- Veterinary Pathology
- Canine Histopathology
- Metabolic Diseases
Background:
- Previously unrecorded canine disease identified.
- Lesions characterized by polyglucosan bodies in multiple organs.
- Neuronal involvement with granular material observed.
Purpose of the Study:
- Describe the histopathology of a novel canine disease.
- Determine the underlying cause of observed lesions.
- Investigate potential inherited metabolic defects.
Main Methods:
- Tissue processing for light and electron microscopy.
- Utilized paraffin wax and epoxy resin embedding.
- Performed various staining techniques on liver, brain, heart, and kidney.
Main Results:
- Periodic acid Schiff (PAS)-positive bodies found in liver and myocardium.
- These bodies are characteristic of polyglucosan body disease.
- Neurons contained similar coarse granular material.
Conclusions:
- Histopathology and distribution of lesions suggest Glycogen storage disease type IV.
- This is an inherited metabolic defect due to glycogen-branching enzyme deficiency.
- This condition has not been previously reported in dogs.
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