Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Encapsulated filtering bleb and subconjunctival 5-fluorouracil.

A Ophir¹, U Ticho

¹Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.

Ophthalmic Surgery

|May 1, 1992

Summary

This study found that 5-fluorouracil (5-FU) improved glaucoma surgery success rates but did not significantly reduce filtering bleb encapsulation (BE). Fibroblast populations involved in scarring and encapsulation appear heterogeneous.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

An uncommon pattern of polyneuropathy induced by lifetime exposures to drift containing organophosphate pesticides.

Neurotoxicology·2014

Same author

Vitreous traction and epiretinal membranes in diabetic macular oedema using spectral-domain optical coherence tomography.

Eye (London, England)·2010

Same author

Extrafoveal vitreous traction associated with diabetic diffuse macular oedema.

Eye (London, England)·2009

Same author

Cystoid foveal oedema in symptomatic inner lamellar macular holes.

Eye (London, England)·2008

Same author

Protection of the conjunctival flap from contact with mitomycin C during tunnel-trabeculectomy.

Eye (London, England)·2006

Same author

Diabetic vitreopapillary traction and macular oedema.

Eye (London, England)·2004

Area of Science:

Ophthalmology
Glaucoma Surgery
Fibroblast Biology

Background:

Filtering bleb encapsulation (BE) is a common complication after glaucoma surgery, involving fibroblast proliferation and collagen synthesis.
This process can impede surgical success by causing scarring.
Understanding factors that influence BE is crucial for improving surgical outcomes.

Purpose of the Study:

To analyze the effect of 5-fluorouracil (5-FU) on the inhibition of filtering bleb encapsulation (BE) after trabeculectomy.
To compare surgical success rates and the incidence of BE in patients treated with and without 5-FU.

Main Methods:

A randomized study involving 41 patients undergoing initial trabeculectomy for primary open-angle glaucoma.
Twenty-one patients received postoperative subconjunctival 5-FU injections, while 20 did not.
Surgical success and BE incidence were assessed at 12 to 24 months post-surgery.

Main Results:

The surgical success rate was significantly higher in the 5-FU treated group (P < .05).
However, the incidence of filtering bleb encapsulation (BE) was similar between the 5-FU treated group (9.5%) and the control group (10%).

Conclusions:

5-fluorouracil (5-FU) enhances surgical success after trabeculectomy but does not significantly reduce filtering bleb encapsulation (BE).
The distinct effects of 5-FU on BE and bleb scarring suggest heterogeneity in the fibroblast populations involved in these processes.

Related Experiment Videos