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Related Experiment Videos

Copper in developmental stuttering.

Per A Alm1

  • 1Department of Clinical Neurosciences, Lund University, Lund, Sweden. Per.Alm@psykiatr.lu.se

Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP)
|July 23, 2005
PubMed
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This study found no link between low blood copper levels and developmental stuttering in adult men. Contrary to previous research, high copper levels correlated with increased muscle activity during stuttering.

Area of Science:

  • Neurobiology
  • Biochemistry
  • Speech and Language Pathology

Background:

  • Previous studies suggested a link between low blood copper and developmental stuttering severity.
  • Copper metabolism disorders can affect basal ganglia function and cause dystonia, a motor disorder with stuttering-like traits.
  • Copper ions are known to influence dopamine and GABA neurotransmitter systems.

Purpose of the Study:

  • To investigate plasma copper levels, ceruloplasmin, and free copper in adult men with developmental stuttering.
  • To determine if previously reported correlations between copper levels and stuttering severity exist in this population.

Main Methods:

  • Compared plasma copper, ceruloplasmin, and estimated free copper in 16 men with developmental stuttering and 16 controls.

Related Experiment Videos

  • Assayed samples in a single batch using pseudorandom and counterbalanced order.

    • Main Results:

    • No significant differences in plasma copper, ceruloplasmin, or free copper were found between stuttering men and controls.
    • No negative correlation was observed between copper levels and general stuttering severity.
    • Exploratory analysis revealed a positive correlation between high plasma copper and superfluous muscle activity during stuttering (r=0.51, p=0.04).

    Conclusions:

    • The findings do not support a relationship between developmental stuttering and low plasma copper in adult men.
    • High plasma copper may be associated with increased motor activity during stuttering events.