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Low morbidity and mortality for bronchoplastic procedures with and without induction therapy
William R Burfeind1, Thomas A D'Amico, Eric M Toloza
1Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA. burfe001@mc.duke.edu
The Annals of Thoracic Surgery
|July 26, 2005
Summary
Bronchoplastic procedures for lung cancer are safe, even after induction therapy. This study found low mortality and morbidity rates, with functional reconstructions in most patients, demonstrating the efficacy of these surgical techniques.
Area of Science:
- Thoracic Surgery
- Surgical Oncology
- Pulmonary Medicine
Background:
- The safety of bronchoplastic procedures following induction chemoradiotherapy remains uncertain.
- This study aimed to evaluate short- and long-term outcomes of bronchoplastic procedures, comparing cases with and without prior induction therapy.
Purpose of the Study:
- To assess the safety and efficacy of bronchoplastic procedures in lung cancer patients.
- To compare outcomes between patients who received induction therapy and those who did not.
Main Methods:
- Retrospective analysis of 73 patients undergoing sleeve lobectomy or bronchoplasty between 1997 and 2004.
- 19 patients received induction therapy (chemotherapy and/or radiation); 54 did not.
- Outcomes analyzed included mortality, early and late morbidity, and need for further interventions.
Main Results:
- Overall 30-day mortality was 2.7% (2/73), with no deaths in the induction therapy group.
- 30-day complication rates were 30% without induction therapy vs. 42% with induction therapy.
- Long-term complication rates were 20% without induction therapy vs. 5% with induction therapy; 70/71 surviving patients had functional reconstructions.
Conclusions:
- Anatomic pulmonary resections using bronchoplastic techniques are associated with low morbidity and mortality.
- These procedures are safe and effective, even when performed after induction therapy for lung cancer.