Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Circulating anticoagulants, antiphospholipids and thrombosis].

J Sampol1, P Sie

  • 1Laboratoire d'hématologie, hôpital de la Conception, Marseille.

La Revue Du Praticien
|March 1, 1992
PubMed
Summary

Antiphospholipid antibodies, also known as lupus anticoagulants, are linked to an increased risk of thrombosis. Detecting these auto-antibodies requires multiple laboratory tests due to their varied nature.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnosis and management of congenital thrombophilia in the era of direct oral anticoagulants.

Thrombosis research·2019
Same author

Comparison of the ecarin chromogenic assay and diluted thrombin time for quantification of dabigatran concentrations: comment.

Journal of thrombosis and haemostasis : JTH·2018
Same author

Intravenous thrombolysis for acute ischaemic stroke in patients on direct oral anticoagulants.

European journal of neurology·2018
Same author

Postauthorization safety study of Clottafact<sup>®</sup> , a triply secured fibrinogen concentrate in acquired fibrinogen deficiency: a prospective observational study.

Vox sanguinis·2017
Same author

Asbestos-related disease in upholsterers.

Archives of environmental & occupational health·2017
Same author

Post-authorization safety study of Clottafact<sup>®</sup> , a triply secured fibrinogen concentrate in congenital afibrinogenemia. A prospective observational study.

Vox sanguinis·2016

Area of Science:

  • Immunology
  • Hematology
  • Autoimmunity

Context:

  • Antiphospholipid antibodies are auto-antibodies detected via immunological assays or coagulation tests.
  • Also termed "lupus anticoagulant," they target anionic phospholipids.
  • Their presence is associated with an elevated risk of thrombosis, particularly in patients with Lupus Erythematosus Disseminatus (LED).

Purpose:

  • To summarize the characteristics and diagnostic challenges of antiphospholipid antibodies.
  • To highlight their association with thrombosis and antiphospholipid syndrome.
  • To underscore the need for standardized diagnostic approaches.

Summary:

  • Antiphospholipid antibodies, including lupus anticoagulants, are auto-antibodies that increase thrombosis risk.
  • They can manifest across various conditions and drug intakes.
  • Diagnosing them is complex, necessitating a combination of tests due to heterogeneity and challenges with weak positives.

Impact:

  • Improved understanding of antiphospholipid antibodies aids in diagnosing conditions like antiphospholipid syndrome.
  • Highlights the clinical significance of detecting these auto-antibodies for thrombosis risk assessment.
  • Emphasizes the ongoing need for standardized and reliable laboratory diagnostic methods.

Related Experiment Videos