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Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels.

Wibke Hellmich1, Jan Regtmeier, Thanh Tu Duong

  • 1Experimental Biophysics and Applied Nanosciences, Physics Faculty, Bielefeld University, Germany.

Langmuir : the ACS Journal of Surfaces and Colloids
|July 27, 2005
PubMed
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Researchers developed new methods to coat poly(dimethylsiloxane) (PDMS) microfluidic devices with poly(oxyethylene) (POE) molecules. This coating reduces unwanted biomolecule adsorption and controls electroosmotic flow (EOF) for improved bioanalytical applications.

Area of Science:

  • Materials Science
  • Surface Chemistry
  • Microfluidics

Background:

  • Poly(dimethylsiloxane) (PDMS) microfluidic devices suffer from biomolecule adsorption and uncontrolled electroosmotic flow (EOF).
  • Effective surface modification is crucial for advanced bioanalytical applications using microfluidics.

Purpose of the Study:

  • To investigate strategies for coating PDMS surfaces with poly(oxyethylene) (POE) molecules.
  • To assess the impact of these coatings on biomolecule adsorption and EOF.

Main Methods:

  • PDMS surface pretreatment using UV irradiation or oxygen plasma.
  • Covalent linkage of POE-silanes and physical adsorption of a triblock-copolymer (F108).
  • Contact angle measurements and atomic force microscopy (AFM) for surface characterization.

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Main Results:

  • Homogeneous attachment of POE-silanes and F108 to PDMS surfaces confirmed by AFM and contact angle measurements.
  • Discussion of different adsorption mechanisms for F108 on hydrophilic and hydrophobic PDMS.
  • Demonstration of reduced EOF in coated PDMS microchannels.

Conclusions:

  • Developed POE-based coatings effectively modify PDMS surfaces for microfluidic applications.
  • The coatings mitigate protein adsorption and enable control over EOF.
  • These advancements are vital for electrokinetic applications in bioanalysis.