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Updated: Aug 16, 2026

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
Published on: January 25, 2018
Presenilin 1: more than just gamma-secretase
T Raemaekers1, C Esselens, W Annaert
1Laboratory for Membrane Trafficking, Center for Human Genetics, Gasthuisberg, K.U. Leuven and V.I.B.04, B-3000 Leuven, Belgium.
Abstract:
Presenilin 1 plays a central catalytic role in the gamma-secretase processing of amyloid precursor protein, Notch and many other substrates. However, this core component clearly mediates independently several other physiological roles in the cell/neuron. Besides its involvement in beta-catenin degradation, we discuss here the recent implication of presenilin 1 in the turnover of the intercellular cell adhesion molecule, telencephalin, through a degradation route that bears autophagic characteristics. Activation of the endosomal/lysosomal system in general and autophagic degradation in particular, is finally briefly discussed in the context of neurodegenerative diseases.
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