Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A model for Rab GTPase localization.

S Pfeffer1

  • 1Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307, USA. pfeffer@stanford.edu

Biochemical Society Transactions
|July 27, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Comparison of Three Analytical Procedures for Oxandrolone Long-Term Metabolite Determination in Urine Samples.

Drug testing and analysis·2026
Same author

The new small-angle X-ray scattering beamline for materials research at PETRA III: SAXSMAT beamline P62.

Journal of synchrotron radiation·2023
Same author

[MicroRNAs and viral infections].

Virologie (Montrouge, France)·2023
Same author

mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding.

Cell·2018
Same author

[Quality assurance and quality management in intensive care].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2015
Same author

Ergonomics of Selected Laparoscopic Procedures - Need for Action?

Biomedizinische Technik. Biomedical engineering·2013
Same journal

Beyond the scaffold: extracellular matrix uptake in breast cancer.

Biochemical Society transactions·2026
Same journal

TDP-43 proteinopathy as a biomarker and therapeutic target in amyotrophic lateral sclerosis.

Biochemical Society transactions·2026
Same journal

Advancing the monitoring of organelle contact sites in vitro and in vivo.

Biochemical Society transactions·2026
Same journal

Mechanisms influencing transient cytoplasmic protein targeting to intracellular lipid droplets.

Biochemical Society transactions·2026
Same journal

Replication associated nuclear DNA mismatch repair across kingdoms.

Biochemical Society transactions·2026
Same journal

Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis.

Biochemical Society transactions·2026
See all related articles

Rab GTPases are key proteins involved in cellular organization. This review explains how these proteins form molecular assemblies to maintain their specific locations on cell membranes.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The human genome encodes nearly 70 Rab GTPases, essential proteins involved in intracellular membrane trafficking.
  • Rab GTPases undergo C-terminal geranylgeranylation, a lipid modification crucial for their membrane association.
  • These proteins are found on the surfaces of various membrane-bound compartments within eukaryotic cells.

Purpose of the Study:

  • To present a working model explaining the mechanisms by which Rab GTPases achieve and maintain their steady-state localizations.
  • To explore the role of Rab GTPases in the formation of macromolecular assemblies and functional microdomains.
  • To highlight the importance of complex protein interactions in Rab protein cellular localization.

Main Methods:

  • This mini-review synthesizes data from multiple laboratories.

Related Experiment Videos

  • It integrates findings on Rab GTPase function, modification, and localization.
  • The review proposes a model based on existing experimental evidence.

    • Main Results:

    • Rab GTPases are proposed to participate in generating macromolecular assemblies.
    • These assemblies contribute to the formation of functional microdomains within specific membrane compartments.
    • Complex interactions involving Rab GTPases are critical for their stable cellular localization.

    Conclusions:

    • Rab GTPase localization is a dynamic process regulated by protein interactions and assembly formation.
    • Understanding these mechanisms provides insight into the spatial organization of cellular compartments.
    • The proposed model offers a framework for future research into Rab GTPase function and regulation.