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Chelated lead and bone lead.

I Tell1, L J Somervaille, U Nilsson

  • 1Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden.

Scandinavian Journal of Work, Environment & Health
|April 1, 1992
PubMed
Summary
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Chelatable lead, measured after calcium disodium edetate infusion, closely correlates with blood lead levels in workers. This indicates chelation primarily reflects soft tissue lead, not the larger skeletal lead burden.

Area of Science:

  • Environmental Health
  • Toxicology
  • Occupational Medicine

Background:

  • Lead exposure poses significant health risks, particularly for workers in lead-related industries.
  • Accurate assessment of total body lead burden is crucial for effective health monitoring and intervention.

Purpose of the Study:

  • To investigate the correlation between blood lead levels and urinary lead excretion after chelation therapy.
  • To examine the relationship between lead levels in different skeletal sites and chelatable lead.
  • To determine if chelatable lead reflects the total skeletal lead burden.

Main Methods:

  • 20 lead workers underwent intravenous infusion of 1g calcium disodium edetate.
  • Blood lead levels were measured and correlated with 24-hour urinary lead excretion.

Related Experiment Videos

  • In vivo X-ray fluorescence was used to measure lead concentrations in tibia, calcaneus, and phalanx bones.
  • Correlations were analyzed between bone lead levels and chelated lead.

    • Main Results:

    • A strong correlation (r=0.86) was observed between blood lead levels and urinary lead excretion post-chelation.
    • Significant correlations were found between lead levels in different bones (tibia/calcaneus: r=0.93; tibia/phalanx: r=0.67; calcaneus/phalanx: r=0.80).
    • Chelation did not significantly alter lead levels in tibia or calcaneus, but correlated with calcaneus lead (r=0.62) in currently exposed workers.

    Conclusions:

    • Chelatable lead primarily represents the blood and soft-tissue lead pool.
    • The skeletal lead content, the largest component of total body burden, is only partially reflected by chelatable lead.
    • Chelation testing may be a useful indicator of recent or ongoing lead exposure rather than total accumulated skeletal lead.