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Childhood bullous pemphigoid: report of three cases

Erika Voltan1, Juliana Yumi Maeda, Mariana Andrade Muniz Silva

  • 1Department of Dermatology, University of São Paulo Medical School, Brazil.

The Journal of Dermatology
|July 27, 2005
PubMed

Insights

Bullous pemphigoid (BP) is rare in children. This study reports three infants with childhood bullous pemphigoid, successfully treated with corticosteroids for complete remission.

Area of Science:

  • Dermatology
  • Pediatrics
  • Immunodermatology

Background:

  • Bullous pemphigoid (BP) is a rare autoimmune blistering disease.
  • Childhood bullous pemphigoid is exceptionally uncommon, with few documented cases.

Purpose of the Study:

  • To report on three rare cases of infantile bullous pemphigoid.
  • To highlight the diagnostic methods and successful treatment of childhood BP.

Main Methods:

  • Histopathological examination of skin biopsies.
  • Direct and indirect immunofluorescence studies.
  • Salt-split skin testing and immunoblotting for antibody detection.

Main Results:

  • Three infants, aged 2-4 months, were diagnosed with bullous pemphigoid.
  • Diagnostic tests confirmed the presence of BP.
  • All patients achieved complete clinical remission following treatment.

Conclusions:

  • Bullous pemphigoid can occur in early infancy.
  • Systemic corticosteroids are an effective treatment for childhood bullous pemphigoid.
  • Early diagnosis and treatment lead to favorable outcomes.

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