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Published on: September 9, 2012
Frequency of thrombophilia in patients with adverse pregnancy outcome
Nazli Hossain1, Tahir Shamsi, Nargis Soomro
1Department of Obstetrics and Gynaecology, Unit 2, Civil Hospital, Karachi.
Objective:
To determine the association between adverse pregnancy outcomes and thrombophilia.
Methods:
This is a descriptive study, incorporating retrospective analysis of patients with recurrent pregnancy losses, intrauterine deaths, abruptio placenta and early onset pre eclampsia. Patients with adverse pregnancy outcomes in whom co-morbid factors were excluded underwent screening for both acquired and inherited thrombophilia.
Results:
A total of 40 patients were screened for acquired and inherited thrombophilia with adverse pregnancy outcomes. Anticardiolipin antibodies were found positive in 55% of patients and 45% of patients were found deficient for natural anticoagulants protein C and S. Two patients were found positive for both acquired and inherited thrombophilia.
Conclusion:
Thrombophilia, both acquired and inherited are associated with adverse pregnancy outcomes. Patients in whom other co-morbid factors are excluded, should be offered screening for thrombophilia. Liaison between hematologist and obstetrician is the corner stone for success.
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