Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microvessel density for melanoma prognosis.

I Depasquale1, W D Thompson

  • 1Department of Plastic Surgery, Aberdeen Royal Infirmary, Aberdeen, UK.

Histopathology
|July 28, 2005
PubMed
Summary

Microvessel density in melanoma predicts recurrence risk. The Chalkley score is a reliable prognostic indicator, especially for thicker tumors, outperforming the Breslow score.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal plasma cortisol's effect on offspring birth weight: a Mendelian Randomisation study.

BMC pregnancy and childbirth·2024
Same author

Achieving Self-Directed Integrated Cancer Aftercare (ASICA) in melanoma: protocol for a randomised patient-focused pilot trial of delivering the ASICA intervention as a means to earlier detection of recurrent and second primary melanoma.

Trials·2019
Same author

The Medico-Legal Aspects of Venereal Disease.

The British journal of venereal diseases·2011
Same author

Angiogenesis assays using chick chorioallantoic membrane.

Methods in molecular medicine·2011
Same author

Excising basal cell carcinomas: comparing the performance of general practitioners, hospital skin specialists and other hospital specialists.

Clinical and experimental dermatology·2008
Same author

Prognosis in human melanoma: PAR-1 expression is superior to other coagulation components and VEGF.

Histopathology·2008

Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Malignant melanoma prognosis relies on standard indicators.
  • Accurate prognostic tools are crucial for patient management and treatment decisions.

Purpose of the Study:

  • To compare microvessel density with standard prognostic indicators in malignant melanoma.
  • To evaluate the Chalkley score technique as a prognostic tool for melanoma recurrence.

Main Methods:

  • Studied 204 malignant melanoma cases from Scotland.
  • Assessed microvessel density using the Chalkley technique on CD31-immunostained sections.
  • Performed multifactorial regression analysis to determine predictive value.

Main Results:

  • Strong correlation found between microvessel density and tumor thickness (P < 0.001).
  • Chalkley estimation reliably predicts melanoma recurrence risk (P < 0.005).
  • The Chalkley score was superior to the Breslow score for melanomas >2 mm thick.

Conclusions:

  • Microvessel assessment via Chalkley score offers reliable prognostic information for melanoma recurrence.
  • This technique is particularly valuable for melanomas exceeding 2 mm in thickness.
  • Further research is needed to determine its utility in predicting response to anti-angiogenic therapies.

Related Experiment Videos