Related Experiment Video
Updated: Aug 16, 2026

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin
Published on: December 23, 2010
Leukotriene B4 receptor and the function of its helix 8
Toshiaki Okuno1, Takehiko Yokomizo, Tetsuya Hori
1Department of Biochemistry and Molecular Biology and Metabolome, Faculty of Medicine, The University of Tokyo, Japan. t-okuno@umin.ac.jp
Abstract:
More than 30 lipid ligands, which express their biological activities through cognate G-protein-coupled receptors (GPCRs), have been reported. Among them, leukotriene B(4) (LTB(4)) is a potent lipid mediator involved in host defense, inflammation, and the immune responses. Two GPCRs for LTB(4) (BLT1 and BLT2) have been cloned and analyzed. Recent studies using genetically engineered mice suggest that BLT1 plays an important role in several inflammatory diseases including ischemic reperfusion tissue injury, atherosclerosis, and bronchial asthma. BLT1 is also a good tool to study the molecular mechanism of GPCR activation and inactivation in vitro. In this brief review, we focus on the biological and biochemical properties of BLT1 with special attention to the putative helix 8 of the receptor.
Related Concept Videos
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Structural Protein Function
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...
Transducer Mechanism: G Protein–Coupled Receptors
GPCRs are also called heptahelical, 7TM, or...
Type IV Collagen of Basal Lamina
A type IV collagen molecule has six alpha chains which can exist in...
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
