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Updated: Aug 16, 2026

A Micropatterning Assay for Measuring Cell Chirality
Published on: March 11, 2022
Enantioselective fluorescent recognition of a soluble "supported" chiral acid: toward a new method for chiral
Zi-Bo Li1, Jing Lin, Ying-Chuan Qin
1Department of Chemistry, University of Virginia, Charlottesville, VA 22904-4319, USA.
Abstract:
The long-chain aliphatic-group-substituted mandelic acid 3c, which is soluble only in THF and insoluble in water and many polar/nonpolar organic solvents, has been synthesized. This unique solubility allows 3c to be easily isolated from reaction mixtures and makes it potentially useful for catalyst screening. The fluorescent sensors (R)- and (S)-1 can be used to determine the ees of various samples of 3c generated from a series of catalyst screening experiments. The fluorescence measurements correlate well with the conventional HPLC-chiral column analysis. This work demonstrates that the enantioselective fluorescent recognition of organic substrates can lead to a fundamentally new method for chiral catalyst screening. [reaction: see text]
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