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Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
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Left ventricular morphology and function in patients with atherosclerotic renovascular disease

Julian R Wright1, Ala'a E Shurrab, Anne Cooper

  • 1Department of Nephrology, Hope Hospital, Salford, UK.

Journal of the American Society of Nephrology : JASN
|July 29, 2005
PubMed

Insights

Atherosclerotic renovascular disease (ARVD) significantly impacts cardiac health, causing widespread abnormalities in heart structure and function even with early renal dysfunction. Early identification of ARVD patients is crucial for managing cardiovascular risks.

Area of Science:

  • Cardiology
  • Nephrology
  • Vascular Medicine

Background:

  • Atherosclerotic renovascular disease (ARVD) is linked to heart disease, but cardiac structure and function in these patients are understudied.
  • Systematic evaluation of cardiac changes in ARVD concerning renal function and anatomy is lacking.

Purpose of the Study:

  • To systematically investigate the epidemiology of cardiac structure and function in patients with ARVD.
  • To examine the relationship between cardiac changes, renal function, renovascular anatomy, and blood pressure (BP) in ARVD.

Main Methods:

  • Cross-sectional study involving 79 ARVD patients and 50 controls.
  • Echocardiography and 24-h ambulatory BP monitoring were performed.
  • Data analyzed based on renal function, renal artery patency, and ARVD laterality.

Main Results:

  • Only 5.1% of ARVD patients had normal cardiac structure and function.
  • ARVD patients showed significantly higher cardiovascular comorbidity, left ventricular (LV) hypertrophy, and LV diastolic dysfunction.
  • ARVD patients had increased LV mass index and LV end-diastolic volume index compared to controls.

Conclusions:

  • ARVD patients exhibit a high prevalence of cardiac abnormalities, even with early renal dysfunction.
  • Renal function or artery patency did not predict echocardiographic or BP parameters in ARVD.
  • Bilateral ARVD was associated with greater LV dilation and mass index.

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