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Updated: Aug 16, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
Corticospinal tract MRI hyperintensity in X-linked Charcot-Marie-Tooth Disease
Jan Kassubek1, Volker Bretschneider, Anne-Dorte Sperfeld
1Department of Neurology, University of Ulm, Ulm, Germany. jan.kassubek@medizin.uni-ulm.de
Abstract:
In X-linked hereditary demyelinating neuropathies (CMTX), caused by mutations in Connexin 32, mild subclinical CNS involvement is not unusual. We present a young male patient suffering from genetically proven CMTX who presented with permanent bilateral corticospinal tract hyperintensities in cranial MRI -- a finding previously described to be characteristic for amyotrophic lateral sclerosis. MRI seems to be able to visualize corticospinal tract abnormalities, even if subclinical, in CMTX.

